اثر 8 هفته تمرین هوازی بر شاخص عملکرد سلول‎های بتای پانکراس و مقاومت به انسولین زنان میانسال مبتلا به دیابت نوع دو

Abstract: Pancreatic &beta;-cells function and insulin sensitivity resistance were impaired in type 2 diabetes. Exercise training may improves these impairs, however, this is not well known. The aim of present study was to examine the Effect of 8 weeks aerobic training on pancreatic &beta;-cells function and insulin resistance in female patients with type 2 diabetes. Methods: Twenty middle-aged women (age, 40 -50 years) with type 2 diabetes participated as the subject. The subjects were randomly assign to control group (n=10) or the training group (n=10). The subjects in the training group performed 30 to 45 min aerobic training on the treadmill with 60- 75% of their maximum heart rate, 3 days a week for 8 weeks. The subjects in the control group were instructed to maintain their normal physical activity throughout the study. Results: The results indicated that fasting blood sugar, fasting insulin and insulin resistance index decrease in the training group compare to the control group (P<0.05); however, pancreatic &beta;-cells function has no significant change after the intervention (P=0.2). Conclusion: In summary, it seems that aerobic training utilized in this study improves glucose entry into cells but it had not effective on pancreatic &beta;-cells function.